|Other Names||DNA nucleotidylexotransferase, Terminal addition enzyme, Terminal deoxynucleotidyltransferase, Terminal transferase, DNTT, TDT|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.|
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This gene is a member of the DNA polymerase type-X familyand encodes a template-independent DNA polymerase that catalyzesthe addition of deoxynucleotides to the 3'-hydroxyl terminus ofoligonucleotide primers. In vivo, the encoded protein is expressedin a restricted population of normal and malignant pre-B and pre-Tlymphocytes during early differentiation, where it generatesantigen receptor diversity by synthesizing non-germ line elements(N-regions) at the junctions of rearranged Ig heavy chain and Tcell receptor gene segments. Alternatively spliced transcriptvariants encoding different isoforms of this gene have beendescribed.
Kubota, T., et al. Genes Cells 12(8):941-959(2007)O'Malley, D.P., et al. Haematologica 91(8):1139-1140(2006)Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)Thai, T.H., et al. J. Immunol. 173(6):4009-4019(2004)Liu, L., et al. Am. J. Clin. Pathol. 121(6):810-815(2004)
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