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RUTBC1 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession O43147
Clone Names 80924187
Peptide ID 80924187
Additional Information
Gene ID 9905
Other Names Small G protein signaling modulator 2, RUN and TBC1 domain-containing protein 1, SGSM2, KIAA0397, RUTBC1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SGSM2
Synonyms KIAA0397, RUTBC1
Function Possesses GTPase activator activity towards RAB32, RAB33B and RAB38 (PubMed:26620560, PubMed:21808068). Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation (PubMed:26620560).
Cellular Location Cytoplasm. Melanosome. Note=Melanosomal localization is mediated by RAB9A.
Tissue Location Widely expressed.
Research Areas
Citations (0)

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Background

The specific function of the protein remains unknown.

References

Vasan, R.S., et al. JAMA 302(2):168-178(2009)Ishibashi, K., et al. Genes Cells 14(1):41-52(2009)Yang, H., et al. Genomics 90(2):249-260(2007)Stelzl, U., et al. Cell 122(6):957-968(2005)

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$ 80.00
Cat# BP11573b
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