|Other Names||Small G protein signaling modulator 2, RUN and TBC1 domain-containing protein 1, SGSM2, KIAA0397, RUTBC1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Possesses GTPase activator activity towards RAB32, RAB33B and RAB38 (PubMed:26620560, PubMed:21808068). Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation (PubMed:26620560).|
|Cellular Location||Cytoplasm. Melanosome. Note=Melanosomal localization is mediated by RAB9A.|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
The specific function of the protein remains unknown.
Vasan, R.S., et al. JAMA 302(2):168-178(2009)Ishibashi, K., et al. Genes Cells 14(1):41-52(2009)Yang, H., et al. Genomics 90(2):249-260(2007)Stelzl, U., et al. Cell 122(6):957-968(2005)
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