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ISWI Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession O60264
Clone Names 81201017
Peptide ID 81201017
Additional Information
Gene ID 8467
Other Names SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5, 364-, Sucrose nonfermenting protein 2 homolog, hSNF2H, SMARCA5, SNF2H, WCRF135
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms SNF2H, WCRF135
Function Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00624, ECO:0000269|PubMed:12434153}
Tissue Location Ubiquitously expressed.
Research Areas
Citations (0)

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The protein encoded by this gene is a member of theSWI/SNF family of proteins. Members of this family have helicaseand ATPase activities and are thought to regulate transcription ofcertain genes by altering the chromatin structure around thosegenes. The protein encoded by this gene is a component of thechromatin remodeling and spacing factor RSF, a facilitator of thetranscription of class II genes by RNA polymerase II. The encodedprotein is similar in sequence to the Drosophila ISWI chromatinremodeling protein.


Goldman, J.A., et al. J. Biol. Chem. 285(7):4645-4651(2010)He, X., et al. Biochemistry 47(27):7025-7033(2008)Sheu, J.J., et al. Cancer Res. 68(11):4050-4057(2008)Olsen, J.V., et al. Cell 127(3):635-648(2006)Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)

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$ 80.00
Cat# BP11583b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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