|Other Names||Voltage-dependent calcium channel gamma-8 subunit, Neuronal voltage-gated calcium channel gamma-8 subunit, Transmembrane AMPAR regulatory protein gamma-8, TARP gamma-8, CACNG8, CACNG6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.|
|Cellular Location||Membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density|
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The protein encoded by this gene is a type I transmembraneAMPA receptor regulatory protein (TARP). TARPs regulate bothtrafficking and channel gating of the AMPA receptors. This gene ispart of a functionally diverse eight-member protein subfamily ofthe PMP-22/EMP/MP20 family and is located in a cluster with twofamily members, a type II TARP and a calcium channel gamma subunit.The mRNA for this gene is believed to initiate translation from anon-AUG (CUG) start codon.
Sager, C., et al. Neuroscience 158(1):45-54(2009)Correia, S.S., et al. Nat. Neurosci. 11(4):457-466(2008)Chen, R.S., et al. Cell Biochem. Biophys. 47(2):178-186(2007)Chu, P.J., et al. Gene 280 (1-2), 37-48 (2001) :Burgess, D.L., et al. Genomics 71(3):339-350(2001)
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