|Other Names||Fibroblast growth factor 17, FGF-17, FGF17|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development.|
|Tissue Location||Preferentially expressed in the embryonic brain|
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The protein encoded by this gene is a member of thefibroblast growth factor (FGF) family. FGF family members possessbroad mitogenic and cell survival activities, and are involved in avariety of biological processes including embryonic developmentcell growth, morphogenesis, tissue repair, tumor growth andinvasion. This gene was shown to be prominently expressed in thecerebellum and cortex. The mouse homolog of this gene was localizedto specific sites in the midline structures of the forebrain, themidbrain-hindbrain junction, developing skeleton and developingarteries, which suggests a role in central nervous system, bone andvascular development. This gene was referred to as FGF-13 inreference 2, however, its amino acid sequence and chromosomallocalization are identical to FGF17.
Wen, Y., et al. Nat. Genet. 41(2):228-233(2009)Moffa, A.B., et al. J. Cell. Physiol. 210(3):720-731(2007)Zhang, X., et al. J. Biol. Chem. 281(23):15694-15700(2006)Olsen, S.K., et al. Genes Dev. 20(2):185-198(2006)Popovici, C., et al. J. Biol. Chem. 279(38):40146-40152(2004)
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