|Other Names||LDLR chaperone MESD, Mesoderm development candidate 2, Mesoderm development protein, Renal carcinoma antigen NY-REN-61, MESDC2, KIAA0081, MESD|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Chaperone specifically assisting the folding of beta- propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction.|
|Cellular Location||Endoplasmic reticulum|
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Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction.
Murrills, R.J., et al. J. Cell. Biochem. 108(5):1066-1075(2009)Li, Y., et al. FEBS Lett. 580(22):5423-5428(2006)Veltman, I.M., et al. Hum. Mol. Genet. 14(14):1955-1963(2005)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)Hsieh, J.C., et al. Cell 112(3):355-367(2003)
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