|Other Names||2-acylglycerol O-acyltransferase 2, Acyl-CoA:monoacylglycerol acyltransferase 2, MGAT2, hMGAT2, Diacylglycerol O-acyltransferase candidate 5, hDC5, Diacylglycerol acyltransferase 2-like protein 5, Monoacylglycerol O-acyltransferase 2, MOGAT2, DC5, DGAT2L5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the formation of diacylglycerol from 2- monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Highly expressed in liver, small intestine, colon, stomach and kidney.|
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Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
Yee, N.S., et al. Cancer Lett. 297(1):49-55(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Kuhn, F.J., et al. J. Biol. Chem. 285(35):26806-26814(2010)Gkika, D., et al. Oncogene 29(32):4611-4616(2010)Van Haute, C., et al. ScientificWorldJournal 10, 1597-1611 (2010) :
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