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PLD1 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q13393 |
|---|---|
| Clone Names | 71211151 |
| Gene ID | 5337 |
|---|---|
| Other Names | Phospholipase D1, PLD 1, hPLD1, Choline phosphatase 1, Phosphatidylcholine-hydrolyzing phospholipase D1, PLD1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PLD1 (HGNC:9067) |
|---|---|
| Function | Function as phospholipase selective for phosphatidylcholine (PubMed:8530346, PubMed:9582313, PubMed:25936805). Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). |
| Cellular Location | Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9Z280}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Z280}; Lipid-anchor {ECO:0000250|UniProtKB:Q9Z280}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9Z280}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9Z280}; Lipid-anchor {ECO:0000250|UniProtKB:Q9Z280}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9Z280}. Late endosome membrane {ECO:0000250|UniProtKB:Q9Z280}; Lipid-anchor {ECO:0000250|UniProtKB:Q9Z280}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9Z280} |
| Tissue Location | Expressed abundantly in the pancreas and heart and at high levels in brain, placenta, spleen, uterus and small intestine |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the bone morphogeneticprotein (BMP) family and the TGF-beta superfamily of secretedsignaling molecules. It is required for normal formation of somebones and joints in the limbs, skull, and axial skeleton. Mutationsin this gene result in colobomata, which are congenitalabnormalities in ocular development, and in Klippel-Feil syndrome(KFS), which is a congenital disorder of spinal segmentation.
References
Gonzalez-Rodriguez, J., et al. Br J Ophthalmol 94(8):1100-1104(2010)Mikic, B., et al. J. Orthop. Res. 27(12):1603-1611(2009)Asai-Coakwell, M., et al. Hum. Mol. Genet. 18(6):1110-1121(2009)Zhang, X., et al. Mol. Vis. 15, 2911-2918 (2009) :Shen, B., et al. Int. J. Biol. Sci. 5(2):192-200(2009)
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