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NCL Antibody (Center E443) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P19338 |
|---|---|
| Clone Names | 80522064 |
| Gene ID | 4691 |
|---|---|
| Other Names | Nucleolin, Protein C23, NCL |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NCL |
|---|---|
| Function | Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG- 3' repeats more tightly than the telomeric single-stranded DNA 5'- TTAGGG-3' repeats. |
| Cellular Location | Nucleus, nucleolus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is the heavy chain of aserine protease inhibitor that may serve to carry hyaluronan inplasma. This gene is part of a cluster of similar genes onchromosome 3. Multiple transcript variants encoding differentisoforms have been found for this gene.
References
So, H.C., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (1), 103-113 (2010) :Scott, L.J., et al. Proc. Natl. Acad. Sci. U.S.A. 106(18):7501-7506(2009)Hamm, A., et al. BMC Cancer 8, 25 (2008) :Scarchilli, L., et al. J. Biol. Chem. 282(41):30161-30170(2007)Bunkenborg, J., et al. Proteomics 4(2):454-465(2004)
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