KNG1 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P01042 |
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Clone Names | 80917033 |
Gene ID | 3827 |
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Other Names | Kininogen-1, Alpha-2-thiol proteinase inhibitor, Fitzgerald factor, High molecular weight kininogen, HMWK, Williams-Fitzgerald-Flaujeac factor, Kininogen-1 heavy chain, T-kinin, Ile-Ser-Bradykinin, Bradykinin, Kallidin I, Lysyl-bradykinin, Kallidin II, Kininogen-1 light chain, Low molecular weight growth-promoting factor, KNG1, BDK, KNG |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | KNG1 |
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Synonyms | BDK, KNG |
Function | Kininogens are inhibitors of thiol proteases. HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. LMW-kininogen inhibits the aggregation of thrombocytes. LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting. |
Cellular Location | Secreted, extracellular space. |
Tissue Location | Secreted in plasma. T-kinin is detected in malignant ovarian, colon and breast carcinomas, but not in benign tumors. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Pyroglutamyl peptidase I (EC 3.4.19.3) catalyzes thehydrolysis of N-terminal pyroglutamyl residues from oligopeptidesand proteins.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :Valdivia, A., et al. Regul. Pept. 122(2):79-84(2004)Minderman, H., et al. Clin. Cancer Res. 10(5):1826-1834(2004)Dando, P.M., et al. Protein Expr. Purif. 28(1):111-119(2003)Gil, J., et al. Neuropeptides 35 (5-6), 276-284 (2001) :
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