PAP Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P51003 |
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Clone Names | 80722081 |
Gene ID | 10914 |
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Other Names | Poly(A) polymerase alpha, PAP-alpha, Polynucleotide adenylyltransferase alpha, PAPOLA, PAP |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PAPOLA |
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Synonyms | PAP |
Function | Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C- terminus. |
Cellular Location | Cytoplasm. Nucleus. Note=The 90 kDa form is nuclear while the 100 kDa and the 106 kDa forms are both nuclear and cytoplasmic |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a nuclear protein with three C2H2-typezinc fingers, and functions as a transcriptional repressor.Chromosomal aberrations involving this gene are associated withendometrial stromal tumors. Alternatively spliced variants whichencode different protein isoforms have been described; however, notall variants have been fully characterized
References
Andersson, E.A., et al. Diabetologia 53(9):1908-1916(2010)Liu, H., et al. Prostate (2010) In press :Voight, B.F., et al. Nat. Genet. 42(7):579-589(2010)Gallagher, D.J., et al. Clin. Cancer Res. 16(10):2819-2832(2010)Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :
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