|Other Names||Poly(A) polymerase alpha, PAP-alpha, Polynucleotide adenylyltransferase alpha, PAPOLA, PAP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus.|
|Cellular Location||Cytoplasm. Nucleus. Note=The 90 kDa form is nuclear while the 100 kDa and the 106 kDa forms are both nuclear and cytoplasmic|
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This gene encodes a nuclear protein with three C2H2-typezinc fingers, and functions as a transcriptional repressor.Chromosomal aberrations involving this gene are associated withendometrial stromal tumors. Alternatively spliced variants whichencode different protein isoforms have been described; however, notall variants have been fully characterized
Andersson, E.A., et al. Diabetologia 53(9):1908-1916(2010)Liu, H., et al. Prostate (2010) In press :Voight, B.F., et al. Nat. Genet. 42(7):579-589(2010)Gallagher, D.J., et al. Clin. Cancer Res. 16(10):2819-2832(2010)Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :
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