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NORE1 Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q8WWW0
Clone Names 81020070
Peptide ID 81020070
Additional Information
Gene ID 83593
Other Names Ras association domain-containing protein 5, New ras effector 1, Regulator for cell adhesion and polarization enriched in lymphoid tissues, RAPL, RASSF5, NORE1, RAPL
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms NORE1, RAPL
Function Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis.
Cellular Location Cytoplasm. Cytoplasm, cytoskeleton. Note=Isoform 2 is mainly located in the perinuclear region of unstimulated primary T-cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A
Tissue Location Widely expressed. Frequently down-regulated in lung tumor cell lines and primary lung tumors
Research Areas
Citations (0)

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The protein encoded by this gene is highly similar to thegene product of Schizosaccharomyces pombe rad17, a cell cyclecheckpoint gene required for cell cycle arrest and DNA damagerepair in response to DNA damage. This protein shares strongsimilarity with DNA replication factor C (RFC), and can form acomplex with RFCs. This protein binds to chromatin prior to DNAdamage and is phosphorylated by the checkpoint kinase ATR followingdamage. This protein recruits the RAD1-RAD9-HUS1 checkpoint proteincomplex onto chromatin after DNA damage, which may be required forits phosphorylation. The phosphorylation of this protein isrequired for the DNA-damage-induced cell cycle G2 arrest, and isthought to be a critical early event during checkpoint signaling inDNA-damaged cells. Eight alternatively spliced transcript variantsof this gene, which encode four distinct proteins, have beenreported. Two pseudogenes, located on chromosomes 7 and 13, havebeen identified.


Zhang, L., et al. EMBO J. 29(10):1726-1737(2010)Vega, A., et al. Gynecol. Oncol. 112(1):210-214(2009)Beretta, G.L., et al. Cancer Lett. 266(2):194-202(2008)Zhao, M., et al. Head Neck 30(1):35-42(2008)Rodriguez-Bravo, V., et al. Cancer Res. 66(17):8672-8679(2006)

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$ 80.00
Cat# BP11698b
Availability: In Stock
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