PAX5 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q02548 |
---|---|
Clone Names | 81110007 |
Gene ID | 5079 |
---|---|
Other Names | Paired box protein Pax-5, B-cell-specific transcription factor, BSAP, PAX5 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PAX5 |
---|---|
Function | Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage (PubMed:10811620, PubMed:27181361). Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage- specific genes (PubMed:10811620, PubMed:27181361). In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage (PubMed:32612238). Repression of the cohesin- release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire (PubMed:32612238). |
Cellular Location | Nucleus. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Lysophospholipases are enzymes that act on biologicalmembranes to regulate the multifunctional lysophospholipids. Theprotein encoded by this gene hydrolyzes lysophosphatidylcholine toglycerophosphorylcholine and a free fatty acid. This enzyme ispresent in the plasma and thought to be associated withhigh-density lipoprotein. A later paper contradicts the function ofthis gene. It demonstrates that this gene encodes a lysosomalenzyme instead of a lysophospholipase and has bothcalcium-independent phospholipase A2 and transacylase activities.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Cucchiara, B.L., et al. Stroke 40(7):2332-2336(2009)Hoffmann, M.M., et al. J. Thromb. Haemost. 7(1):41-48(2009)Schaloske, R.H., et al. Biochim. Biophys. Acta 1761(11):1246-1259(2006)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.