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FAM102A Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q5T9C2 |
|---|---|
| Clone Names | 91218014 |
| Gene ID | 399665 |
|---|---|
| Other Names | Protein FAM102A, Early estrogen-induced gene 1 protein, FAM102A, C9orf132, EEIG1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | EEIG1 {ECO:0000303|PubMed:14605097, ECO:0000312|HGNC:HGNC:31419} |
|---|---|
| Function | Key component of TNFSF11/RANKL- and TNF-induced osteoclastogenesis pathways, thereby mediates bone resorption in pathological bone loss conditions (By similarity). Required for TNFSF11/RANKL-induced osteoclastogenesis via its interaction with TNFRSF11A/RANK, thereby facilitates the downsteam transcription of NFATC1 and activation of PLCG2 (By similarity). Facilitates recruitment of the transcriptional repressor PRDM1/BLIMP1 to the promoter of the anti-osteoclastogenesis gene IRF8, thereby resulting in transcription of osteoclast differentiation factors (By similarity). May play a role in estrogen action (PubMed:14605097). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q78T81}. Cytoplasm {ECO:0000250|UniProtKB:Q78T81}. Membrane raft {ECO:0000250|UniProtKB:Q78T81} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Members of the CELF/BRUNOL protein family contain twoN-terminal RNA recognition motif (RRM) domains, one C-terminal RRMdomain, and a divergent segment of 160-230 aa between the secondand third RRM domains. Members of this protein family regulatepre-mRNA alternative splicing and may also be involved in mRNAediting, and translation. Multiple alternatively spliced transcriptvariants encoding different isoforms have been identified in thisgene.
References
Ladd, A.N., et al. J. Biol. Chem. 279(17):17756-17764(2004)Wistow, G., et al. Mol. Vis. 8, 205-220 (2002) :Good, P.J., et al. J. Biol. Chem. 275(37):28583-28592(2000)
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