|Other Names||Protein SHQ1 homolog, SHQ1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA.|
|Cellular Location||Cytoplasm, cytosol. Nucleus, nucleoplasm. Note=May at least partially shuttle between cytosol and nucleoplasm. In the nucleoplasm, exhibits a granular pattern, but is excluded from nucleoli and Cajal bodies Absent from most H/ACA-box RNA transcription sites|
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The protein encoded by this gene is a helix-loop-helix(HLH) protein that can form heterodimers with members of the basicHLH family of transcription factors. The encoded protein has no DNAbinding activity and therefore can inhibit the DNA binding andtranscriptional activation ability of basic HLH proteins with whichit interacts. This protein may play a role in cell growth,senescence, and differentiation. Two transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].
Qian, T., et al. Oncogene 29(43):5818-5827(2010)Hamajima, Y., et al. Cell Prolif. 43(5):457-463(2010)Yang, J., et al. Circ. Res. 107(2):252-262(2010)Phi, J.H., et al. J Neurosurg Pediatr 5(6):608-614(2010)Geng, H., et al. Cancer Res. 70(8):3239-3248(2010)
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