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TAF1 Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P21675
Clone Names 71130172
Peptide ID 71130172
Additional Information
Gene ID 6872
Other Names Transcription initiation factor TFIID subunit 1, Cell cycle gene 1 protein, TBP-associated factor 250 kDa, p250, Transcription initiation factor TFIID 250 kDa subunit, TAF(II)250, TAFII-250, TAFII250, TAF1, BA2R, CCG1, CCGS, TAF2A
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TAF1
Synonyms BA2R, CCG1, CCGS, TAF2A
Function Largest component and core scaffold of the TFIID basal transcription factor complex (PubMed:25412659, PubMed:27007846). Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2- mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity (PubMed:25412659). Essential for progression of the G1 phase of the cell cycle (PubMed:11278496, PubMed:15053879, PubMed:2038334, PubMed:8450888, PubMed:8625415, PubMed:9660973, PubMed:9858607). Exhibits histone acetyltransferase activity towards histones H3 and H4 (PubMed:15870300).
Cellular Location Nucleus
Research Areas
Citations (0)

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This gene is a member of the small GTPase superfamily andencodes a lipid-anchored, cell membrane protein with five repeatsof the RAS-related GTP-binding region. This protein is vital inregulation of growth and cell cycle progression due to its role inthe insulin/TOR/S6K signaling pathway. The protein has GTPaseactivity and shuttles between a GDP-bound form and a GTP-boundform, and farnesylation of the protein is required for thisactivity. Three pseudogenes have been mapped, two on chromosome 10and one on chromosome 22.


Zheng, H., et al. Cancer Lett. 297(1):117-125(2010)Kim, H.W., et al. Mol. Cell. Biol. 30(22):5406-5420(2010)Karassek, S., et al. J. Biol. Chem. 285(44):33979-33991(2010)Wagner, R.J., et al. Am. J. Physiol., Cell Physiol. 299 (1), C119-C127 (2010) :Lu, Z.H., et al. Cancer Res. 70(8):3287-3298(2010)

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$ 80.00
Cat# BP11765b
Availability: In Stock
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