|Other Names||Transcription initiation factor TFIID subunit 1, Cell cycle gene 1 protein, TBP-associated factor 250 kDa, p250, Transcription initiation factor TFIID 250 kDa subunit, TAF(II)250, TAFII-250, TAFII250, TAF1, BA2R, CCG1, CCGS, TAF2A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||BA2R, CCG1, CCGS, TAF2A|
|Function||Largest component and core scaffold of the TFIID basal transcription factor complex (PubMed:25412659, PubMed:27007846). Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2- mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity (PubMed:25412659). Essential for progression of the G1 phase of the cell cycle (PubMed:11278496, PubMed:15053879, PubMed:2038334, PubMed:8450888, PubMed:8625415, PubMed:9660973, PubMed:9858607). Exhibits histone acetyltransferase activity towards histones H3 and H4 (PubMed:15870300).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the small GTPase superfamily andencodes a lipid-anchored, cell membrane protein with five repeatsof the RAS-related GTP-binding region. This protein is vital inregulation of growth and cell cycle progression due to its role inthe insulin/TOR/S6K signaling pathway. The protein has GTPaseactivity and shuttles between a GDP-bound form and a GTP-boundform, and farnesylation of the protein is required for thisactivity. Three pseudogenes have been mapped, two on chromosome 10and one on chromosome 22.
Zheng, H., et al. Cancer Lett. 297(1):117-125(2010)Kim, H.W., et al. Mol. Cell. Biol. 30(22):5406-5420(2010)Karassek, S., et al. J. Biol. Chem. 285(44):33979-33991(2010)Wagner, R.J., et al. Am. J. Physiol., Cell Physiol. 299 (1), C119-C127 (2010) :Lu, Z.H., et al. Cancer Res. 70(8):3287-3298(2010)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.