|Other Names||Transcription initiation factor TFIID subunit 1, Cell cycle gene 1 protein, TBP-associated factor 250 kDa, p250, Transcription initiation factor TFIID 250 kDa subunit, TAF(II)250, TAFII-250, TAFII250, TAF1, BA2R, CCG1, CCGS, TAF2A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||BA2R, CCG1, CCGS, TAF2A|
|Function||Largest component and core scaffold of the TFIID basal transcription factor complex (PubMed:25412659, PubMed:27007846). Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2- mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity (PubMed:25412659). Essential for progression of the G1 phase of the cell cycle (PubMed:11278496, PubMed:15053879, PubMed:2038334, PubMed:8450888, PubMed:8625415, PubMed:9660973, PubMed:9858607). Exhibits histone acetyltransferase activity towards histones H3 and H4 (PubMed:15870300).|
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This gene is a member of the small GTPase superfamily andencodes a lipid-anchored, cell membrane protein with five repeatsof the RAS-related GTP-binding region. This protein is vital inregulation of growth and cell cycle progression due to its role inthe insulin/TOR/S6K signaling pathway. The protein has GTPaseactivity and shuttles between a GDP-bound form and a GTP-boundform, and farnesylation of the protein is required for thisactivity. Three pseudogenes have been mapped, two on chromosome 10and one on chromosome 22.
Zheng, H., et al. Cancer Lett. 297(1):117-125(2010)Kim, H.W., et al. Mol. Cell. Biol. 30(22):5406-5420(2010)Karassek, S., et al. J. Biol. Chem. 285(44):33979-33991(2010)Wagner, R.J., et al. Am. J. Physiol., Cell Physiol. 299 (1), C119-C127 (2010) :Lu, Z.H., et al. Cancer Res. 70(8):3287-3298(2010)
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