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S100A1 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P23297 |
|---|---|
| Clone Names | 80722090 |
| Gene ID | 6271 |
|---|---|
| Other Names | Protein S100-A1, S-100 protein alpha chain, S-100 protein subunit alpha, S100 calcium-binding protein A1, S100A1, S100A |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | S100A1 |
|---|---|
| Synonyms | S100A |
| Function | Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation (PubMed:12804600). In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes (PubMed:23351007). These changes allow interactions with specific target proteins and modulate their activity (PubMed:22399290). Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase (PubMed:12804600). Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole (PubMed:11717446). |
| Cellular Location | Cytoplasm. Sarcoplasmic reticulum. Mitochondrion {ECO:0000250|UniProtKB:P56565} |
| Tissue Location | Highly prevalent in heart (PubMed:12804600, PubMed:1384693). Also found in lesser quantities in skeletal muscle and brain (PubMed:1384693). |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the beta tubulin proteinfamily. Beta tubulins are one of two core protein families (alphaand beta tubulins) that heterodimerize and assemble to formmicrotubules. This protein is specifically expressed in plateletsand megakaryocytes and may be involved in proplatelet productionand platelet release. A mutations in this gene is associated withautosomal dominant macrothrombocytopenia. Two pseudogenes of thisgene are found on chromosome Y.
References
Anton, A.I., et al. Ann. Hematol. 89(11):1147-1154(2010)Yin, S., et al. Mol. Cancer Ther. 9(2):327-335(2010)Xu, W., et al. Mol. Cancer Ther. 8(12):3318-3330(2009)Joe, P.A., et al. J. Biol. Chem. 284(7):4283-4291(2009)Navarro-Nunez, L., et al. Thromb. Haemost. 100(6):1211-1213(2008)
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