|Other Names||Protein S100-A1, S-100 protein alpha chain, S-100 protein subunit alpha, S100 calcium-binding protein A1, S100A1, S100A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.|
|Tissue Location||Highly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain|
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This gene encodes a member of the beta tubulin proteinfamily. Beta tubulins are one of two core protein families (alphaand beta tubulins) that heterodimerize and assemble to formmicrotubules. This protein is specifically expressed in plateletsand megakaryocytes and may be involved in proplatelet productionand platelet release. A mutations in this gene is associated withautosomal dominant macrothrombocytopenia. Two pseudogenes of thisgene are found on chromosome Y.
Anton, A.I., et al. Ann. Hematol. 89(11):1147-1154(2010)Yin, S., et al. Mol. Cancer Ther. 9(2):327-335(2010)Xu, W., et al. Mol. Cancer Ther. 8(12):3318-3330(2009)Joe, P.A., et al. J. Biol. Chem. 284(7):4283-4291(2009)Navarro-Nunez, L., et al. Thromb. Haemost. 100(6):1211-1213(2008)
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