|Other Names||Nucleotide-binding oligomerization domain-containing protein 2, Caspase recruitment domain-containing protein 15, Inflammatory bowel disease protein 1, NOD2, CARD15, IBD1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3 and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:18511561).|
|Cellular Location||Cytoplasm. Membrane. Basolateral cell membrane|
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The protein encoded by this gene is a member of the S100family of proteins containing 2 EF-hand calcium-binding motifs.S100 proteins are localized in the cytoplasm and/or nucleus of awide range of cells, and involved in the regulation of a number ofcellular processes such as cell cycle progression anddifferentiation. S100 genes include at least 13 members which arelocated as a cluster on chromosome 1q21. This protein may functionin motility, invasion, and tubulin polymerization. Chromosomalrearrangements and altered expression of this gene have beenimplicated in tumor metastasis. Multiple alternatively splicedvariants, encoding the same protein, have been identified.
Ma, X., et al. Cancer Lett. 299(2):171-181(2010)Miranda, K.J., et al. J. Biol. Chem. 285(41):31517-31524(2010)van Dieck, J., et al. FEBS Lett. 584(15):3269-3274(2010)Cunningham, M.F., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 299 (2), G457-G466 (2010) :Mencia, N., et al. BMC Cancer 10, 250 (2010) :
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