CMGA Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P10645 |
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Clone Names | 80808024 |
Gene ID | 1113 |
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Other Names | Chromogranin-A, CgA, Pituitary secretory protein I, SP-I, Vasostatin-1, Vasostatin I, Vasostatin-2, Vasostatin II, EA-92, ES-43, Pancreastatin, SS-18, WA-8, WE-14, LF-19, AL-11, GV-19, GR-44, ER-37, CHGA |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CHGA |
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Function | [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. |
Cellular Location | [Serpinin]: Secreted {ECO:0000250|UniProtKB:P26339}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:P26339}. Note=Pyroglutaminated serpinin localizes to secretory vesicle. {ECO:0000250|UniProtKB:P26339} |
Tissue Location | Detected in cerebrospinal fluid (at protein level) (PubMed:25326458). Detected in urine (at protein level) (PubMed:37453717). |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the BCL2/adenovirus E1B 19kd-interacting protein (BNIP) family. It interacts with the E1B 19kDa protein which is responsible for the protection ofvirally-induced cell death, as well as E1B 19 kDa-like sequences ofBCL2, also an apoptotic protector. The protein encoded by thisgene is a functional homolog of BNIP3, a proapoptotic protein.This protein may function simultaneously with BNIP3 and may play arole in tumor suppression.
References
Novak, I., et al. EMBO Rep. 11(1):45-51(2010)Bellot, G., et al. Mol. Cell. Biol. 29(10):2570-2581(2009)Wang, L., et al. Cancer Epidemiol. Biomarkers Prev. 17(12):3558-3566(2008)Papandreou, I., et al. Cell Death Differ. 15(10):1572-1581(2008)Liu, W., et al. Neoplasia 10(8):897-907(2008)
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