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NUP107 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P57740 |
|---|---|
| Clone Names | 81028099 |
| Gene ID | 57122 |
|---|---|
| Other Names | Nuclear pore complex protein Nup107, 107 kDa nucleoporin, Nucleoporin Nup107, NUP107 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NUP107 |
|---|---|
| Function | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:12552102, PubMed:15229283, PubMed:30179222). Required for the assembly of peripheral proteins into the NPC (PubMed:15229283, PubMed:12552102). May anchor NUP62 to the NPC (PubMed:15229283). Involved in nephrogenesis (PubMed:30179222). |
| Cellular Location | Nucleus membrane. Nucleus, nuclear pore complex. Chromosome, centromere, kinetochore. Note=Located on both the cytoplasmic and nuclear sides of the NPC core structure (PubMed:11564755). During mitosis, localizes to the kinetochores (PubMed:11564755). Dissociates from the dissasembled NPC structure late during prophase of mitosis (PubMed:11564755) |
| Tissue Location | Ubiquitously expressed in fetal and adult tissues. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene product is a sequence-specific, single-strandedDNA-binding protein. It binds preferentially to the single strandof the purine-rich element termed PUR, which is present at originsof replication and in gene flanking regions in a variety ofeukaryotes from yeasts through humans. Thus, it is implicated inthe control of both DNA replication and transcription. Deletion ofthis gene has been associated with myelodysplastic syndrome andacute myelogenous leukemia.
References
Inoue, T., et al. Prostate 69(8):861-873(2009)Martins-de-Souza, D., et al. Eur Arch Psychiatry Clin Neurosci 259(3):151-163(2009)Kaminski, R., et al. Cancer Biol. Ther. 7(12):1926-1935(2008)Darbinian, N., et al. J. Alzheimers Dis. 15(1):71-82(2008)Wang, L.G., et al. Cancer Res. 68(8):2678-2688(2008)
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