|Other Names||Phosphomannomutase 1, PMM 1, PMMH-22, PMM1, PMMH22|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain.|
|Tissue Location||Strong expression in liver, heart, brain, and pancreas; lower expression in skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a sperm protein, whichinteracts with A-kinase anchoring protein, AKAP3, through theamphipathic helix region of AKAP3. Type II regulatory subunit ofcAMP-dependent protein kinase (PKARII) also binds to this helixdomain of AKAP3, which allows PKARII to be targeted to specificsubcellular compartments. It is suggested that sperm containsseveral proteins that bind to AKAPs in a manner similar to PKARII,and this encoded protein may be one of them.
Carr, D.W., et al. J. Biol. Chem. 276(20):17332-17338(2001)
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