|Other Names||Interstitial collagenase, Fibroblast collagenase, Matrix metalloproteinase-1, MMP-1, 22 kDa interstitial collagenase, 27 kDa interstitial collagenase, MMP1, CLG|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
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Provided below are standard protocols that you may find useful for product applications.
Proteins of the matrix metalloproteinase (MMP) family areinvolved in the breakdown of extracellular matrix in normalphysiological processes, such as embryonic development,reproduction, and tissue remodeling, as well as in diseaseprocesses, such as arthritis and metastasis. Most MMP's aresecreted as inactive proproteins which are activated when cleavedby extracellular proteinases. This gene encodes a secreted enzymewhich breaks down the interstitial collagens, types I, II, and III.The gene is part of a cluster of MMP genes which localize tochromosome 11q22.3. Alternative splicing results in multipletranscript variants.
Beshir, A.B., et al. Cancer Lett. 299(2):137-149(2010)Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Malik, N., et al. J. Neurooncol. (2010) In press :Skorupski, P., et al. Ginekol. Pol. 81(8):594-599(2010)Mossbock, G., et al. Mol. Vis. 16, 1764-1770 (2010) :
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