|Other Names||Tumor necrosis factor ligand superfamily member 15, TNF ligand-related molecule 1, Vascular endothelial cell growth inhibitor, Tumor necrosis factor ligand superfamily member 15, membrane form, Tumor necrosis factor ligand superfamily member 15, secreted form, TNFSF15, TL1, VEGI|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.|
|Cellular Location||Membrane; Single-pass type II membrane protein|
|Tissue Location||Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a cytokine thatbelongs to the tumor necrosis factor (TNF) ligand family. Thisprotein is abundantly expressed in endothelial cells, but is notexpressed in either B or T cells. The expression of this protein isinducible by TNF and IL-1 alpha. This cytokine is a ligand forreceptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activateNF-kappaB and MAP kinases, and acts as an autocrine factor toinduce apoptosis in endothelial cells. This cytokine is also foundto inhibit endothelial cell proliferation, and thus may function asan angiogenesis inhibitor. An additional isoform encoded by analternatively spliced transcript variant has been reported but thesequence of this transcript has not been determined. [provided byRefSeq].
Amre, D.K., et al. Hum. Genet. 128(2):131-135(2010)Heidemann, S.C., et al. J. Clin. Immunol. 30(4):531-538(2010)McLaren, J.E., et al. J. Immunol. 184(10):5827-5834(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Nakagome, S., et al. Ann. Hum. Genet. 74(2):126-136(2010)
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