|Other Names||Neuronal acetylcholine receptor subunit alpha-2, CHRNA2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.|
|Cellular Location||Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein|
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Nicotinic acetylcholine receptors (nAChRs) areligand-gated ion channels formed by a pentameric arrangement ofalpha and beta subunits to create distinct muscle and neuronalreceptors. Neuronal receptors are found throughout the peripheraland central nervous system where they are involved in fast synaptictransmission. This gene encodes an alpha subunit that is widelyexpressed in the brain. The proposed structure for nAChR subunitsis a conserved N-terminal extracellular domain followed by threeconserved transmembrane domains, a variable cytoplasmic loop, afourth conserved transmembrane domain, and a short C-terminalextracellular region. Mutations in this gene cause autosomaldominant nocturnal frontal lobe epilepsy type 4. Single nucleotidepolymorphisms (SNPs) in this gene have been associated withnicotine dependence.
Saccone, N.L., et al. Genes Brain Behav. 9(7):741-750(2010)Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)Rigbi, A., et al. Pharmacogenomics J. (2010) In press :Hoda, J.C., et al. FEBS Lett. 583(10):1599-1604(2009)Philibert, R.A., et al. Nicotine Tob. Res. 11(3):286-292(2009)
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