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RAP1GDS1 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P52306 |
|---|---|
| Clone Names | 101008083 |
| Gene ID | 5910 |
|---|---|
| Other Names | Rap1 GTPase-GDP dissociation stimulator 1, Exchange factor smgGDS, SMG GDS protein, SMG P21 stimulatory GDP/GTP exchange protein, RAP1GDS1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | RAP1GDS1 {ECO:0000303|Ref.3} |
|---|---|
| Synonyms | SMGGDS {ECO:0000303|Ref.3} |
| Function | Acts as a GEF (guanine nucleotide exchange factor) for the Rho family of small GTP-binding proteins (G proteins) that stimulates the dissociation of GDP to enable subsequent binding of GTP (PubMed:28630045, PubMed:30190425, PubMed:1549351, PubMed:11948427, PubMed:20709748). Additionally, appears to chaperone the processing and/or trafficking of small GTPases containing a C-terminal polybasic region independently of GEF activity (PubMed:20709748, PubMed:21242305). Targets include RAP1A/RAP1B, RHOA, RHOB, RHOC, RAC1 and KRAS (PubMed:1549351, PubMed:11948427, PubMed:20709748, PubMed:24415755). Regulates mitochondrial dynamics by controlling RHOT function to promote mitochondrial fission during high calcium conditions (PubMed:27716788). Able to promote the Ca(2+) release from the endoplasmic reticulum via both inositol trisphosphate (Ins3P) and ryanodine sensitive receptors leading to a enhanced mitochondrial Ca(2+) uptake (PubMed:24349085). |
| Cellular Location | Cytoplasm, cytosol. Endoplasmic reticulum. Mitochondrion. Nucleus Note=Nuclear import is dependent on complexing with a GTPase containing a C-terminal polybasic region. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The smg GDP dissociation stimulator (smgGDS) protein is astimulatory GDP/GTP exchange protein with GTPase activity (Riess etal., 1993 [PubMed 8262526]).
References
Schonherr, C., et al. Oncogene 29(19):2817-2830(2010)Branham, M.T., et al. J. Biol. Chem. 284(37):24825-24839(2009)Zemunik, T., et al. Croat. Med. J. 50(1):23-33(2009)Tew, G.W., et al. J. Biol. Chem. 283(2):963-976(2008)Tiwari, S., et al. Blood 103(7):2661-2667(2004)
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