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RGS7 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P49802
Clone Names 100528060
Peptide ID 100528060
Additional Information
Gene ID 6000
Other Names Regulator of G-protein signaling 7, RGS7, RGS7
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RGS7
Function Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:10521509, PubMed:10862767). The RGS7/GNB5 dimer enhances GNAO1 GTPase activity (PubMed:10521509). May play a role in synaptic vesicle exocytosis (PubMed:12659861). Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling (PubMed:15897264).
Cellular Location Cytoplasm, cytosol. Cytoplasm. Cell membrane. Membrane; Peripheral membrane protein; Cytoplasmic side Note=Interaction with PKD1 promotes location at the cell membrane (PubMed:10339594). Interaction with RGS7BP promotes location at the cell membrane (PubMed:15897264).
Research Areas
Citations (0)

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Background

RGS7 inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/GNG5 dimer. May play a role in synaptic vesicle exocytosis. May play important role in the rapid regulation of neuronal excitability and the cellular responses to short-lived stimulations (By similarity).

References

Bailey, S.D., et al. Diabetes Care (2010) In press :Wang, J., et al. Carcinogenesis (2010) In press :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)McCauley, J.L., et al. Genes Immun. 10(7):624-630(2009)

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$ 80.00
Cat# BP12015b
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