|Other Names||Protocadherin-1, Cadherin-like protein 1, Protocadherin-42, PC42, PCDH1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in cell-cell interaction processes and in cell adhesion.|
|Cellular Location||Cell junction. Cell membrane; Single-pass type I membrane protein. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries|
|Tissue Location||Highly expressed in the brain and neuro-glial cells|
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This gene belongs to the protocadherin subfamily withinthe cadherin superfamily. The encoded protein is a membrane proteinfound at cell-cell boundaries. It is involved in neural celladhesion, suggesting a possible role in neuronal development. Theprotein includes an extracelllular region, containing 7cadherin-like domains, a transmembrane region and a C-terminalcytoplasmic region. Cells expressing the protein showed cellaggregation activity. Alternative splicing occurs in this gene.
Koppelman, G.H., et al. Am. J. Respir. Crit. Care Med. 180(10):929-935(2009)Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)Ballif, B.A., et al. Mol. Cell Proteomics 3(11):1093-1101(2004)Ballif, B.A., et al. Mol. Cell Proteomics 3(11):1093-1101(2004)Colland, F., et al. Genome Res. 14(7):1324-1332(2004)
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