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TXNRD1 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q16881 |
|---|---|
| Clone Names | 101008090 |
| Gene ID | 7296 |
|---|---|
| Other Names | Thioredoxin reductase 1, cytoplasmic, TR, Gene associated with retinoic and interferon-induced mortality 12 protein, GRIM-12, Gene associated with retinoic and IFN-induced mortality 12 protein, KM-102-derived reductase-like factor, Thioredoxin reductase TR1, TXNRD1, GRIM12, KDRF |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TXNRD1 (HGNC:12437) |
|---|---|
| Synonyms | GRIM12, KDRF |
| Function | Reduces disulfideprotein thioredoxin (Trx) to its dithiol- containing form (PubMed:8577704). Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. Contains a selenocysteine residue at the C-terminal active site that is essential for catalysis (Probable). Also has reductase activity on hydrogen peroxide (H2O2) (PubMed:10849437). |
| Cellular Location | [Isoform 1]: Cytoplasm [Isoform 5]: Cytoplasm |
| Tissue Location | [Isoform 1]: Expressed predominantly in Leydig cells (at protein level). Also expressed in ovary, spleen, heart, liver, kidney and pancreas and in a number of cancer cell lines |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the family of pyridinenucleotide oxidoreductases. This protein reduces thioredoxins aswell as other substrates, and plays a role in selenium metabolismand protection against oxidative stress. The functional enzyme isthought to be a homodimer which uses FAD as a cofactor. Eachsubunit contains a selenocysteine (Sec) residue which is requiredfor catalytic activity. The selenocysteine is encoded by the UGAcodon that normally signals translation termination. The 3' UTR ofselenocysteine-containing genes have a common stem-loop structure,the sec insertion sequence (SECIS), that is necessary for therecognition of UGA as a Sec codon rather than as a stop signal.Alternative splicing results in several transcript variantsencoding the same or different isoforms.
References
Turanov, A.A., et al. Biochem. J. 430(2):285-293(2010)Javvadi, P., et al. Cancer Res. 70(5):1941-1950(2010)Engstrom, K.S., et al. Mutat. Res. 683 (1-2), 98-105 (2010) :Cadenas, C., et al. Breast Cancer Res. 12 (3), R44 (2010) :Volonte, D., et al. EMBO Rep. 10(12):1334-1340(2009)
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