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TXNRD1 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q16881
Clone Names 101008090
Peptide ID 101008090
Additional Information
Gene ID 7296
Other Names Thioredoxin reductase 1, cytoplasmic, TR, Gene associated with retinoic and interferon-induced mortality 12 protein, GRIM-12, Gene associated with retinoic and IFN-induced mortality 12 protein, KM-102-derived reductase-like factor, Thioredoxin reductase TR1, TXNRD1, GRIM12, KDRF
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms GRIM12, KDRF
Function Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.
Cellular Location Cytoplasm. Isoform 5: Cytoplasm.
Tissue Location Isoform 1 is expressed predominantly in Leydig cells (at protein level). Also expressed in ovary, spleen, heart, liver, kidney and pancreas and in a number of cancer cell lines Isoform 4 is widely expressed with highest levels in kidney, testis, uterus, ovary, prostate, placenta and fetal liver
Research Areas
Citations (0)

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This gene encodes a member of the family of pyridinenucleotide oxidoreductases. This protein reduces thioredoxins aswell as other substrates, and plays a role in selenium metabolismand protection against oxidative stress. The functional enzyme isthought to be a homodimer which uses FAD as a cofactor. Eachsubunit contains a selenocysteine (Sec) residue which is requiredfor catalytic activity. The selenocysteine is encoded by the UGAcodon that normally signals translation termination. The 3' UTR ofselenocysteine-containing genes have a common stem-loop structure,the sec insertion sequence (SECIS), that is necessary for therecognition of UGA as a Sec codon rather than as a stop signal.Alternative splicing results in several transcript variantsencoding the same or different isoforms.


Turanov, A.A., et al. Biochem. J. 430(2):285-293(2010)Javvadi, P., et al. Cancer Res. 70(5):1941-1950(2010)Engstrom, K.S., et al. Mutat. Res. 683 (1-2), 98-105 (2010) :Cadenas, C., et al. Breast Cancer Res. 12 (3), R44 (2010) :Volonte, D., et al. EMBO Rep. 10(12):1334-1340(2009)

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$ 80.00
Cat# BP12022a
Availability: In Stock
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