|Other Names||AP-1 complex subunit mu-1, AP-mu chain family member mu1A, Adaptor protein complex AP-1 subunit mu-1, Adaptor-related protein complex 1 subunit mu-1, Clathrin assembly protein complex 1 mu-1 medium chain 1, Clathrin coat assembly protein AP47, Clathrin coat-associated protein AP47, Golgi adaptor HA1/AP1 adaptin mu-1 subunit, Mu-adaptin 1, Mu1A-adaptin, AP1M1, CLTNM|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.|
|Cellular Location||Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex|
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The protein encoded by this gene is the medium chain ofthe trans-Golgi network clathrin-associated protein complex AP-1.The other components of this complex are beta-prime-adaptin,gamma-adaptin, and the small chain AP1S1. This complex is locatedat the Golgi vesicle and links clathrin to receptors in coatedvesicles. These vesicles are involved in endocytosis and Golgiprocessing. Alternatively spliced transcript variants encodingdistinct protein isoforms have been found for this gene. [providedby RefSeq].
Sawasdee, N., et al. Biochem. Biophys. Res. Commun. 401(1):85-91(2010)Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)Noviello, C.M., et al. J. Virol. 82(3):1249-1258(2008)Medigeshi, G.R., et al. Traffic 9(1):121-132(2008)Roeth, J.F., et al. J. Cell Biol. 167(5):903-913(2004)
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