|Other Names||Docking protein 3, Downstream of tyrosine kinase 3, DOK3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity).|
|Cellular Location||Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side|
|Tissue Location||Expressed in spleen.|
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DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate Abl function (By similarity).
Berger, A.H., et al. Nat. Genet. 42(3):216-223(2010)Senis, Y.A., et al. J. Thromb. Haemost. 7(10):1718-1726(2009)Honma, M., et al. Genes Cells 11(2):143-151(2006)Robson, J.D., et al. Mol. Cell. Biol. 24(6):2332-2343(2004)Favre, C., et al. Genes Immun. 4(1):40-45(2003)
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