DOK3 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q7L591 |
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Clone Names | 101008016 |
Gene ID | 79930 |
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Other Names | Docking protein 3, Downstream of tyrosine kinase 3, DOK3 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | DOK3 |
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Function | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity). |
Cellular Location | Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side |
Tissue Location | Expressed in spleen.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate Abl function (By similarity).
References
Berger, A.H., et al. Nat. Genet. 42(3):216-223(2010)Senis, Y.A., et al. J. Thromb. Haemost. 7(10):1718-1726(2009)Honma, M., et al. Genes Cells 11(2):143-151(2006)Robson, J.D., et al. Mol. Cell. Biol. 24(6):2332-2343(2004)Favre, C., et al. Genes Immun. 4(1):40-45(2003)
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