|Other Names||Aminoacylase-1, ACY-1, N-acyl-L-amino-acid amidohydrolase, ACY1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate).|
|Tissue Location||Expression is highest in kidney, strong in brain and weaker in placenta and spleen|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a cytosolic, homodimeric, zinc-bindingenzyme that catalyzes the hydrolysis of acylated L-amino acids toL-amino acids and an acyl group, and has been postulated tofunction in the catabolism and salvage of acylated amino acids.This gene is located on chromosome 3p21.1, a region reduced tohomozygosity in small-cell lung cancer (SCLC), and its expressionhas been reported to be reduced or undetectable in SCLC cell linesand tumors. The amino acid sequence of human aminoacylase-1 ishighly homologous to the porcine counterpart, and this enzyme isthe first member of a new family of zinc-binding enzymes. Mutationsin this gene cause aminoacylase-1 deficiency, a metabolic disordercharacterized by central nervous system defects and increasedurinary excretion of N-acetylated amino acids. Alternative splicingof this gene results in multiple transcript variants. Read-throughtranscription also exists between this gene and the upstreamABHD14A (abhydrolase domain containing 14A) gene, as represented inGeneID:100526760. A related pseudogene has been identified onchromosome 18.
Tylki-Szymanska, A., et al. J. Inherit. Metab. Dis. (2010) In press :Lindner, H.A., et al. Biochemistry 47(14):4266-4275(2008)Sass, J.O., et al. Neurology 68(24):2151-2153(2007)Sass, J.O., et al. Am. J. Hum. Genet. 78(3):401-409(2006)Van Coster, R.N., et al. Biochem. Biophys. Res. Commun. 338(3):1322-1326(2005)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.