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TGIF1 Antibody (Center A160) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q15583
Clone Names 71017129
Peptide ID 71017129
Additional Information
Gene ID 7050
Other Names Homeobox protein TGIF1, 5'-TG-3'-interacting factor 1, TGIF1, TGIF
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TGIF1
Synonyms TGIF
Function Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII- RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities.
Cellular Location Nucleus.
Research Areas
Citations (0)

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The protein encoded by this gene is a member of thethree-amino acid loop extension (TALE) superclass of atypicalhomeodomains. TALE homeobox proteins are highly conservedtranscription regulators. This particular homeodomain binds to apreviously characterized retinoid X receptor responsive elementfrom the cellular retinol-binding protein II promoter. In additionto its role in inhibiting 9-cis-retinoic acid-dependent RXR alphatranscription activation of the retinoic acid responsive element,the protein is an active transcriptional co-repressor of SMAD2 andmay participate in the transmission of nuclear signals duringdevelopment and in the adult. Mutations in this gene are associatedwith holoprosencephaly type 4, which is a structural anomaly of thebrain. Alternative splicing has been observed at this locus andeight variants, encoding four distinct isoforms, are described.


Bengoechea-Alonso, M.T., et al. Oncogene 29(38):5322-5328(2010)Paulussen, A.D., et al. Eur. J. Hum. Genet. 18(9):999-1005(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Demange, C., et al. Mol. Cell 36(6):1073-1085(2009)Hamid, R., et al. Mol Oncol 3 (5-6), 451-463 (2009) :

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$ 80.00
Cat# BP12062c
Availability: In Stock
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