|Other Names||Histone-lysine N-methyltransferase SUV420H1, Lysine N-methyltransferase 5B, Suppressor of variegation 4-20 homolog 1, Su(var)4-20 homolog 1, Suv4-20h1, SUV420H1, KMT5B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3.|
|Cellular Location||Nucleus. Chromosome. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity).|
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This gene encodes a protein that contains a SET domain.SET domains appear to be protein-protein interaction domains thatmediate interactions with a family of proteins that displaysimilarity with dual-specificity phosphatases (dsPTPases). Thefunction of this gene has not been determined. Two alternativelyspliced transcript variants have been found for this gene.
Chinenov, Y., et al. Proc. Natl. Acad. Sci. U.S.A. 105(51):20185-20190(2008)Yang, H., et al. J. Biol. Chem. 283(18):12085-12092(2008)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Tryndyak, V.P., et al. Cancer Biol. Ther. 5(1):65-70(2006)Twells, R.C., et al. Genomics 72(3):231-242(2001)
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