|Other Names||Histone acetyltransferase KAT2B, Histone acetyltransferase PCAF, Histone acetylase PCAF, Lysine acetyltransferase 2B, P300/CBP-associated factor, P/CAF, KAT2B, PCAF|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers.|
|Tissue Location||Ubiquitously expressed but most abundant in heart and skeletal muscle.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
CBP and p300 are large nuclear proteins that bind to manysequence-specific factors involved in cell growth and/ordifferentiation, including c-jun and the adenoviral oncoproteinE1A. The protein encoded by this gene associates with p300/CBP. Ithas in vitro and in vivo binding activity with CBP and p300, andcompetes with E1A for binding sites in p300/CBP. It has histoneacetyl transferase activity with core histones and nucleosome coreparticles, indicating that this protein plays a direct role intranscriptional regulation.
Perez, R.E., et al. J. Cell. Physiol. 225(2):394-405(2010)Mooney, S.M., et al. J. Biol. Chem. 285(40):30443-30452(2010)Aoyama, T., et al. J. Biol. Chem. 285(39):29842-29850(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Shimahara, A., et al. J. Biol. Chem. 285(22):16967-16977(2010)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.