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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   PCAF Antibody (N-term) Blocking peptide   

PCAF Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q92831
Clone Names 71130170
Peptide ID 71130170
Additional Information
Gene ID 8850
Other Names Histone acetyltransferase KAT2B, Histone acetyltransferase PCAF, Histone acetylase PCAF, Lysine acetyltransferase 2B, P300/CBP-associated factor, P/CAF, KAT2B, PCAF
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name KAT2B
Synonyms PCAF
Function Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers.
Cellular Location Nucleus.
Tissue Location Ubiquitously expressed but most abundant in heart and skeletal muscle.
Research Areas
Citations (0)

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CBP and p300 are large nuclear proteins that bind to manysequence-specific factors involved in cell growth and/ordifferentiation, including c-jun and the adenoviral oncoproteinE1A. The protein encoded by this gene associates with p300/CBP. Ithas in vitro and in vivo binding activity with CBP and p300, andcompetes with E1A for binding sites in p300/CBP. It has histoneacetyl transferase activity with core histones and nucleosome coreparticles, indicating that this protein plays a direct role intranscriptional regulation.


Perez, R.E., et al. J. Cell. Physiol. 225(2):394-405(2010)Mooney, S.M., et al. J. Biol. Chem. 285(40):30443-30452(2010)Aoyama, T., et al. J. Biol. Chem. 285(39):29842-29850(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Shimahara, A., et al. J. Biol. Chem. 285(22):16967-16977(2010)

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$ 80.00
Cat# BP12074a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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