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MDK Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P21741
Clone Names 71211133
Peptide ID 71211133
Additional Information
Gene ID 4192
Other Names Midkine, MK, Amphiregulin-associated protein, ARAP, Midgestation and kidney protein, Neurite outgrowth-promoting factor 2, Neurite outgrowth-promoting protein, MDK, MK1, NEGF2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MDK
Synonyms MK1, NEGF2
Function Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity).
Cellular Location Secreted.
Tissue Location Expressed in various tumor cell lines. In insulinoma tissue predominantly expressed in precancerous lesions
Research Areas
Citations (0)

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Midkine is a retinoic acid-responsive, heparin-bindinggrowth factor expressed in various cell types during embryogenesis.It promotes angiogenesis, cell growth, and cell migration. Midkineis also expressed in several carcinomas, suggesting that it mayplay a role in tumorigenesis, perhaps through its effects onangiogenesis (summary by Reynolds et al., 2004 [PubMed15197188]).


Ferreira, R.C., et al. Nat. Genet. 42(9):777-780(2010)Kerzerho, J., et al. J. Immunol. 185(1):418-423(2010)Yao, X., et al. Acta Pharmacol. Sin. 31(5):629-637(2010)Zhang, Z.H., et al. Cell Prolif. 43(2):184-194(2010)Rice, G.E., et al. J. Exp. Clin. Cancer Res. 29, 62 (2010) :

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$ 80.00
Cat# BP12076b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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