|Other Names||Probable dimethyladenosine transferase, DIM1 dimethyladenosine transferase 1 homolog, DIM1 dimethyladenosine transferase 1-like, Probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase, Probable 18S rRNA dimethylase, Probable S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase, DIMT1, DIMT1L|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1207a was selected from the N-term region of human DIMT1L. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle (PubMed:25851604). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity (PubMed:25851604).|
|Cellular Location||Nucleus, nucleoplasm. Nucleus, nucleolus|
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Provided below are standard protocols that you may find useful for product applications.
DIMT1L specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.
Law,S.F., Zhang,Y.Z. Mol. Cell. Biol. 18 (6), 3540-3551 (1998)Stanchi,F., Bertocco,E. Yeast 18 (1), 69-80 (2001)
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