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CFD Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P00746 |
|---|---|
| Clone Names | 80513095 |
| Gene ID | 1675 |
|---|---|
| Other Names | Complement factor D, Adipsin, C3 convertase activator, Properdin factor D, CFD, DF, PFD |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CFD |
|---|---|
| Synonyms | DF, PFD |
| Function | Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. |
| Cellular Location | Secreted. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of thetrypsin family of peptidases. The encoded protein is a component ofthe alternative complement pathway best known for its role inhumoral suppression of infectious agents. This protein is also aserine protease that is secreted by adipocytes into thebloodstream. Finally, the encoded protein has a high level ofexpression in fat, suggesting a role for adipose tissue in immunesystem biology.
References
Bailey, S.D., et al. Diabetes Care (2010) In press :Hietaharju, A., et al. Eur. J. Neurol. 17(2):332-334(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Ciprandi, G., et al. Int. Immunopharmacol. 9(12):1460-1463(2009)Cerhan, J.R., et al. Br. J. Haematol. 145(5):614-623(2009)
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