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KCNQ1 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P51787
Clone Names 100311148
Peptide ID 100311148
Additional Information
Gene ID 3784
Other Names Potassium voltage-gated channel subfamily KQT member 1, IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1, KQT-like 1, Voltage-gated potassium channel subunit Kv71, KCNQ1, KCNA8, KCNA9, KVLQT1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name KCNQ1
Synonyms KCNA8, KCNA9, KVLQT1
Function Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea.
Cellular Location Cell membrane; Multi-pass membrane protein Cytoplasmic vesicle membrane; Multi- pass membrane protein
Tissue Location Abundantly expressed in heart, pancreas, prostate, kidney, small intestine and peripheral blood leukocytes Less abundant in placenta, lung, spleen, colon, thymus, testis and ovaries
Research Areas
Citations (0)

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This gene encodes a voltage-gated potassium channelrequired for the repolarization phase of the cardiac actionpotential. The gene product can form heteromultimers with two otherpotassium channel proteins, KCNE1 and KCNE3. Mutations in this geneare associated with hereditary long QT syndrome (also known asRomano-Ward syndrome), Jervell and Lange-Nielsen syndrome andfamilial atrial fibrillation. The gene is located in a region ofchromosome 11 that contains a number of contiguous genes, which areabnormally imprinted in cancer and the Beckwith-Wiedemann syndrome.This gene is also imprinted, with preferential expression from thematernal allele in some tissues, excluding cardiac muscle.Alternatively spliced transcripts encoding distinct isoforms havebeen described.


Nakajo, K., et al. Proc. Natl. Acad. Sci. U.S.A. 107(44):18862-18867(2010)Ren, X.Q., et al. Am. J. Physiol. Heart Circ. Physiol. 299 (5), H1525-H1534 (2010) :Tester, D.J., et al. Am. J. Cardiol. 106(8):1124-1128(2010)Stuebe, A.M., et al. Am. J. Obstet. Gynecol. 203 (3), 283 (2010) :Mohammad, F., et al. Epigenetics 4(5):277-286(2009)

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$ 80.00
Cat# BP12143a
(40 western blots)
Availability: In Stock
Bulk Size
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