|Other Names||Potassium voltage-gated channel subfamily KQT member 1, IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1, KQT-like 1, Voltage-gated potassium channel subunit Kv71, KCNQ1, KCNA8, KCNA9, KVLQT1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||KCNA8, KCNA9, KVLQT1|
|Function||Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea.|
|Cellular Location||Cell membrane; Multi-pass membrane protein Cytoplasmic vesicle membrane; Multi- pass membrane protein|
|Tissue Location||Abundantly expressed in heart, pancreas, prostate, kidney, small intestine and peripheral blood leukocytes Less abundant in placenta, lung, spleen, colon, thymus, testis and ovaries|
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This gene encodes a voltage-gated potassium channelrequired for the repolarization phase of the cardiac actionpotential. The gene product can form heteromultimers with two otherpotassium channel proteins, KCNE1 and KCNE3. Mutations in this geneare associated with hereditary long QT syndrome (also known asRomano-Ward syndrome), Jervell and Lange-Nielsen syndrome andfamilial atrial fibrillation. The gene is located in a region ofchromosome 11 that contains a number of contiguous genes, which areabnormally imprinted in cancer and the Beckwith-Wiedemann syndrome.This gene is also imprinted, with preferential expression from thematernal allele in some tissues, excluding cardiac muscle.Alternatively spliced transcripts encoding distinct isoforms havebeen described.
Nakajo, K., et al. Proc. Natl. Acad. Sci. U.S.A. 107(44):18862-18867(2010)Ren, X.Q., et al. Am. J. Physiol. Heart Circ. Physiol. 299 (5), H1525-H1534 (2010) :Tester, D.J., et al. Am. J. Cardiol. 106(8):1124-1128(2010)Stuebe, A.M., et al. Am. J. Obstet. Gynecol. 203 (3), 283 (2010) :Mohammad, F., et al. Epigenetics 4(5):277-286(2009)
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