|Other Names||PHD finger protein 20, Glioma-expressed antigen 2, Hepatocellular carcinoma-associated antigen 58, Novel zinc finger protein, Transcription factor TZP, PHF20, C20orf104, GLEA2, HCA58, NZF, TZP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||C20orf104, GLEA2, HCA58, NZF, TZP|
|Function||Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage.|
|Tissue Location||Expressed in heart, kidney, liver, lung, pancreas, placenta, spleen and testis. Not expressed in brain, skeletal muscle, colon, ovary, prostate, small intestine and thymus. Expressed in colon and ovary cancer cell lines while it is not expressed in the respective normal tissues|
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PHF20 is possible a transcription factor.
Bankovic, J., et al. Lung Cancer 67(2):151-159(2010)Heisel, S.M., et al. PLoS ONE 3 (5), E2164 (2008) :Olsen, J.V., et al. Cell 127(3):635-648(2006)Pallasch, C.P., et al. Int. J. Cancer 117(3):456-459(2005)Dou, Y., et al. Cell 121(6):873-885(2005)
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