|Other Names||Tau-tubulin kinase 2, TTBK2, KIAA0847|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro.|
|Cellular Location||Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytosol. Nucleus. Note=Localizes to the transition zone in primary cilia in response to cell cycle signals that promote ciliogenesis (By similarity). May also be present in cytosol and, at lower level in the nucleus|
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a serine-threonine kinase thatputatively phosphorylates tau and tubulin proteins. Mutations inthis gene cause spinocerebellar ataxia type 11 (SCA11); aneurodegenerative disease characterized by progressive ataxia andatrophy of the cerebellum and brainstem.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Xu, Q., et al. Neurol. Sci. 31(1):107-109(2010)Edener, U., et al. J. Neurol. 256(11):1856-1859(2009)Houlden, H., et al. Nat. Genet. 39(12):1434-1436(2007)Kitano-Takahashi, M., et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 63 (PT 7), 602-604 (2007) :
If you have any additional inquiries please email technical services at firstname.lastname@example.org.