|Other Names||Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform, CAM-PRP catalytic subunit, Calcineurin, testis-specific catalytic subunit, Calmodulin-dependent calcineurin A subunit gamma isoform, PPP3CC, CALNA3, CNA3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.|
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Calmodulin-dependent protein phosphatase, calcineurin, isinvolved in a wide range of biologic activities, acting as aCa(2+)-dependent modifier of phosphorylation status. In testis, themotility of the sperm is thought to be controlled by cAMP-dependentphosphorylation and a unique form of calcineurin appears to beassociated with the flagellum. The calcineurin holoenzyme iscomposed of catalytic and regulatory subunits of 60 and 18 kD,respectively. At least 3 genes, calcineurin A-alpha (CALNA1; MIM114105), calcineurin A-beta (CALNA2; MIM 114106), and calcineurinA-gamma (CALNA3), have been cloned for the catalytic subunit. Thesegenes have been identified in humans, mice, and rats, and arehighly conserved between species (90 to 95% amino acididentity).
Liu, Y.J., et al. Obesity (Silver Spring) 18(12):2339-2346(2010)He, Z.H., et al. Eur. J. Appl. Physiol. 110(4):761-767(2010)Saus, E., et al. J Psychiatr Res 44(14):971-978(2010)Kyogoku, C., et al. Psychiatry Res (2010) In press :Pelak, K., et al. J. Infect. Dis. 201(8):1141-1149(2010)
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