PPP3CC Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P48454 |
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Clone Names | 101008236 |
Gene ID | 5533 |
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Other Names | Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform, CAM-PRP catalytic subunit, Calcineurin, testis-specific catalytic subunit, Calmodulin-dependent calcineurin A subunit gamma isoform, PPP3CC, CALNA3, CNA3 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PPP3CC |
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Synonyms | CALNA3, CNA3 |
Function | Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32. |
Cellular Location | Mitochondrion {ECO:0000250|UniProtKB:P48455}. Note=Localizes in the mitochondria in a SPATA33-dependent manner {ECO:0000250|UniProtKB:P48455} |
Tissue Location | Testis.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Calmodulin-dependent protein phosphatase, calcineurin, isinvolved in a wide range of biologic activities, acting as aCa(2+)-dependent modifier of phosphorylation status. In testis, themotility of the sperm is thought to be controlled by cAMP-dependentphosphorylation and a unique form of calcineurin appears to beassociated with the flagellum. The calcineurin holoenzyme iscomposed of catalytic and regulatory subunits of 60 and 18 kD,respectively. At least 3 genes, calcineurin A-alpha (CALNA1; MIM114105), calcineurin A-beta (CALNA2; MIM 114106), and calcineurinA-gamma (CALNA3), have been cloned for the catalytic subunit. Thesegenes have been identified in humans, mice, and rats, and arehighly conserved between species (90 to 95% amino acididentity).
References
Liu, Y.J., et al. Obesity (Silver Spring) 18(12):2339-2346(2010)He, Z.H., et al. Eur. J. Appl. Physiol. 110(4):761-767(2010)Saus, E., et al. J Psychiatr Res 44(14):971-978(2010)Kyogoku, C., et al. Psychiatry Res (2010) In press :Pelak, K., et al. J. Infect. Dis. 201(8):1141-1149(2010)
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