|Other Names||Forkhead box protein E3, Forkhead-related protein FKHL12, Forkhead-related transcription factor 8, FREAC-8, FOXE3, FKHL12, FREAC8|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis and cell cycle (PubMed:22527307, PubMed:25504734). During lens development, controls the ratio of the lens fiber cells to the cells of the anterior lens epithelium by regulating the rate of proliferation and differentiation (By similarity). Controls lens vesicle closure and subsequent separation of the lens vesicle from ectoderm (By similarity). Is required for morphogenesis and differentiation of the anterior segment of the eye (By similarity).|
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This intronless gene belongs to the forkhead family oftranscription factors, which is characterized by a distinctforkhead domain. The protein encoded functions as a lens-specifictranscription factor and plays an important role in vertebrate lensformation. Mutations in this gene are associated with anteriorsegment mesenchymal dysgenesis and congenital primary aphakia.
Reis, L.M., et al. Am. J. Med. Genet. A 152A (3), 582-590 (2010) :Bremond-Gignac, D., et al. Mol. Vis. 16, 1705-1711 (2010) :Ali, M., et al. Mol. Vis. 16, 1162-1168 (2010) :Anjum, I., et al. Mol. Vis. 16, 549-555 (2010) :Iseri, S.U., et al. Hum. Mutat. 30(10):1378-1386(2009)
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