|Other Names||Torsin-2A, Torsin family 2 member A, Torsin-related protein 1, TOR2A, TORP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Endoplasmic reticulum lumen.|
|Tissue Location||Isoform 1 is expressed ubiquitously, except in cardiac and endothelial tissues.|
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Salusins are multifunctional bioactive peptides discovered by bioinformatics analyses of a full-length cDNA library. Salusin alpha and salusin beta are related peptides of 28 and 20 amino acids that were recently characterized. These peptides are considered to be biosynthesized from preprosalusin, an alternative-splicing product of the torsion dystonia-related gene (TOR2A), after frameshift reading and digestion at dibasic amino acids. Salusin alpha has recently been shown to be involved in atherosclerosis; it potently suppresses acyl-CoA:cholesterol acyltransferase-1 which stores cholesterol ester converted from free cholesterol in macrophages, thereby reducing human macrophage foam cell formation.
O'Farrell, C.A., et al. Neuroscience 164(3):1127-1137(2009)Sato, K., et al. Peptides 29(12):2203-2207(2008)Watanabe, T., et al. Hypertens. Res. 31(3):463-468(2008)Wang, Z., et al. Eur. J. Pharmacol. 539(3):145-150(2006)Humphray, S.J., et al. Nature 429(6990):369-374(2004)
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