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RPGR Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q92834
Clone Names 100311165
Peptide ID 100311165
Additional Information
Gene ID 6103
Other Names X-linked retinitis pigmentosa GTPase regulator, RPGR, RP3, XLRP3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms RP3, XLRP3
Function Could be a guanine-nucleotide releasing factor. Plays a role in ciliogenesis. Probably regulates cilia formation by regulating actin stress filaments and cell contractility. Plays an important role in photoreceptor integrity. May play a critical role in spermatogenesis and in intraflagellar transport processes (By similarity). May be involved in microtubule organization and regulation of transport in primary cilia.
Cellular Location Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q9R0X5}. Golgi apparatus
Tissue Location Heart, brain, placenta, lung, liver, muscle, kidney, retina, pancreas and fetal retinal pigment epithelium Isoform 3 is found only in the retina. Colocalizes with RPGRIP1 in the outer segment of rod photoreceptors and cone outer segments
Research Areas
Citations (0)

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This gene encodes a protein with a series of six RCC1-likedomains (RLDs), characteristic of the highly conserved guaninenucleotide exchange factors. The encoded protein is found in theGolgi body and interacts with RPGRIP1. This protein localizes tothe outer segment of rod photoreceptors and is essential for theirviability. Mutations in this gene have been associated withX-linked retinitis pigmentosa (XLRP). Multiple alternativelyspliced transcript variants that encode different isoforms of thisgene have been reported, but the full-length natures of only somehave been determined.


Clark, G.R., et al. Ophthalmology 117(11):2169-2177(2010)Schmid, F., et al. Invest. Ophthalmol. Vis. Sci. 51(3):1628-1635(2010)Ji, Y., et al. Curr. Eye Res. 35(1):73-79(2010)Sheng, X., et al. Mol. Vis. 16, 1620-1628 (2010) :Murga-Zamalloa, C.A., et al. J. Genet. 88(4):399-407(2009)

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$ 80.00
Cat# BP12226b
Availability: In Stock
Bulk Size
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