|Other Names||Sphingomyelin phosphodiesterase, Acid sphingomyelinase, aSMase, SMPD1, ASM|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Converts sphingomyelin to ceramide (PubMed:1840600, PubMed:18815062, PubMed:27659707, PubMed:25920558). Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol.|
|Cellular Location||Lysosome. Secreted|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a lysosomal acidsphingomyelinase that converts sphingomyelin to ceramide. Theencoded protein also has phospholipase C activity. Defects in thisgene are a cause of Niemann-Pick disease type A (NPA) andNiemann-Pick disease type B (NPB). Multiple transcript variantsencoding different isoforms have been identified. [provided byRefSeq].
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Desnick, J.P., et al. Mol. Med. 16 (7-8), 316-321 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Sleat, D.E., et al. Mol. Cell Proteomics 5(4):686-701(2006)
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