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SMPD1 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P17405 |
|---|---|
| Clone Names | 100311173 |
| Gene ID | 6609 |
|---|---|
| Other Names | Sphingomyelin phosphodiesterase, Acid sphingomyelinase, aSMase, SMPD1, ASM |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SMPD1 (HGNC:11120) |
|---|---|
| Function | Converts sphingomyelin to ceramide (PubMed:1840600, PubMed:18815062, PubMed:27659707, PubMed:25920558, PubMed:25339683, PubMed:33163980, PubMed:12563314). Exists as two enzymatic forms that arise from alternative trafficking of a single protein precursor, one that is targeted to the endolysosomal compartment, whereas the other is released extracellularly (PubMed:21098024, PubMed:9660788, PubMed:20807762). However, in response to various forms of stress, lysosomal exocytosis may represent a major source of the secretory form (PubMed:20530211, PubMed:12563314, PubMed:20807762, PubMed:9393854, PubMed:22573858). |
| Cellular Location | Lysosome. Lipid droplet. Secreted. Note=The secreted form is induced in a time- and dose-dependent by IL1B and TNF as well as stress and viral infection. This increase of the secreted form seems to be due to exocytosis of the lysosomal form and is Ca(2+)-dependent (PubMed:20807762, PubMed:22573858, PubMed:20530211). Secretion is dependent of phosphorylation at Ser-510 (PubMed:17303575). Secretion is induced by inflammatory mediators such as IL1B, IFNG or TNF as well as infection with bacteria and viruses (PubMed:12563314, PubMed:20807762) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a lysosomal acidsphingomyelinase that converts sphingomyelin to ceramide. Theencoded protein also has phospholipase C activity. Defects in thisgene are a cause of Niemann-Pick disease type A (NPA) andNiemann-Pick disease type B (NPB). Multiple transcript variantsencoding different isoforms have been identified. [provided byRefSeq].
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Desnick, J.P., et al. Mol. Med. 16 (7-8), 316-321 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Sleat, D.E., et al. Mol. Cell Proteomics 5(4):686-701(2006)
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