|Other Names||Pulmonary surfactant-associated protein A2, PSP-A, PSPA, SP-A, SP-A2, 35 kDa pulmonary surfactant-associated protein, Alveolar proteinosis protein, Collectin-5, SFTPA2, COLEC5, PSAP, SFTP1, SFTPA, SFTPA2B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||COLEC5, PSAP, SFTP1, SFTPA, SFTPA2B|
|Function||In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.|
|Cellular Location||Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film|
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This gene is one of several genes encodingpulmonary-surfactant associated proteins (SFTPA) located onchromosome 10. Mutations in this gene and a highly similar genelocated nearby, which affect the highly conserved carbohydraterecognition domain, are associated with idiopathic pulmonaryfibrosis. The current version of the assembly displays only asingle centromeric SFTPA gene pair rather than the two gene pairsshown in the previous assembly which were thought to have resultedfrom a duplication.
Silveyra, P., et al. Am. J. Physiol. Lung Cell Mol. Physiol. 299 (4), L523-L534 (2010) :Maitra, M., et al. J. Biol. Chem. 285(29):22103-22113(2010)Wang, G., et al. J. Biol. Chem. 285(16):11998-12010(2010)El Saleeby, C.M., et al. J. Pediatr. 156(3):409-414(2010)Liu, J., et al. Tohoku J. Exp. Med. 221(1):35-42(2010)
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