SFTPA2B Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8IWL1 |
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Clone Names | 100311192 |
Gene ID | 729238 |
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Other Names | Pulmonary surfactant-associated protein A2, PSP-A, PSPA, SP-A, SP-A2, 35 kDa pulmonary surfactant-associated protein, Alveolar proteinosis protein, Collectin-5, SFTPA2, COLEC5, PSAP, SFTP1, SFTPA, SFTPA2B |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SFTPA2 |
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Synonyms | COLEC5, PSAP, SFTP1, SFTPA, SFTPA2B |
Function | In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air- liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. |
Cellular Location | Secreted. Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is one of several genes encodingpulmonary-surfactant associated proteins (SFTPA) located onchromosome 10. Mutations in this gene and a highly similar genelocated nearby, which affect the highly conserved carbohydraterecognition domain, are associated with idiopathic pulmonaryfibrosis. The current version of the assembly displays only asingle centromeric SFTPA gene pair rather than the two gene pairsshown in the previous assembly which were thought to have resultedfrom a duplication.
References
Silveyra, P., et al. Am. J. Physiol. Lung Cell Mol. Physiol. 299 (4), L523-L534 (2010) :Maitra, M., et al. J. Biol. Chem. 285(29):22103-22113(2010)Wang, G., et al. J. Biol. Chem. 285(16):11998-12010(2010)El Saleeby, C.M., et al. J. Pediatr. 156(3):409-414(2010)Liu, J., et al. Tohoku J. Exp. Med. 221(1):35-42(2010)
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