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NT5C2 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P49902 |
|---|---|
| Clone Names | 101008044 |
| Gene ID | 22978 |
|---|---|
| Other Names | Cytosolic purine 5'-nucleotidase, Cytosolic 5'-nucleotidase II, NT5C2, NT5B, NT5CP, PNT5 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NT5C2 (HGNC:8022) |
|---|---|
| Synonyms | NT5B, NT5CP, PNT5 |
| Function | Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates (PubMed:1659319, PubMed:9371705, PubMed:10092873, PubMed:12907246). In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucleoside, preferably inosine, deoxyinosine and guanosine (PubMed:1659319, PubMed:9371705). Has the highest activities for IMP and GMP followed by dIMP, dGMP and XMP (PubMed:1659319, PubMed:9371705, PubMed:10092873, PubMed:12907246). Could also catalyze the transfer of phosphates from pyrimidine monophosphates but with lower efficiency (PubMed:1659319, PubMed:9371705). Through these activities regulates the purine nucleoside/nucleotide pools within the cell (PubMed:1659319, PubMed:9371705, PubMed:10092873, PubMed:12907246). |
| Cellular Location | Cytoplasm, cytosol. |
| Tissue Location | Widely expressed.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Purine 5-prime-nucleotidase (EC 3.1.3.5) preferentiallyhydrolyzes inosine 5-prime-monophosphate (IMP) and other purinenucleotides, and is allosterically activated by various compounds,including ATP. The enzyme is exclusively located in the cytoplasmicmatrix of cells and may have a critical role in the maintenance ofa constant composition of intracellular purine/pyrimidinenucleotides in cooperation with other nucleotidases.[supplied byOMIM].
References
Niu, W., et al. Clin. Chim. Acta 411 (19-20), 1491-1495 (2010) :Yamauchi, T., et al. Biochem. Pharmacol. 77(12):1780-1786(2009)Newton-Cheh, C., et al. Nat. Genet. (2009) In press :Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)Jordheim, L.P., et al. Drug Metab. Dispos. 36(12):2419-2423(2008)
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