|Other Names||Integrator complex subunit 1, Int1, INTS1, KIAA1440|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.|
|Cellular Location||Nucleus membrane; Single-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
INTS1 is a subunit of the Integrator complex, whichassociates with the C-terminal domain of RNA polymerase II largesubunit (POLR2A; MIM 180660) and mediates 3-prime end processing ofsmall nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690)(Baillat et al., 2005 [PubMed 16239144]).
Nusbaum, C., et al. Nature 439(7074):331-335(2006)Baillat, D., et al. Cell 123(2):265-276(2005)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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