|Other Names||25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial, 25-OHD-1 alpha-hydroxylase, 25-hydroxyvitamin D(3) 1-alpha-hydroxylase, VD3 1A hydroxylase, Calcidiol 1-monooxygenase, Cytochrome P450 subfamily XXVIIB polypeptide 1, Cytochrome P450C1 alpha, Cytochrome P450VD1-alpha, Cytochrome p450 27B1, CYP27B1, CYP1ALPHA, CYP27B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the conversion of 25-hydroxyvitamin D3 (25(OH)D) to 1-alpha,25-dihydroxyvitamin D3 (1,25(OH)2D) plays an important role in normal bone growth, calcium metabolism, and tissue differentiation.|
|Cellular Location||Mitochondrion membrane.|
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This gene encodes a member of the cytochrome P450superfamily of enzymes. The cytochrome P450 proteins aremonooxygenases which catalyze many reactions involved in drugmetabolism and synthesis of cholesterol, steroids and other lipids.The protein encoded by this gene localizes to the innermitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3at the 1alpha position. This reaction synthesizes1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, whichbinds to the vitamin D receptor and regulates calcium metabolism.Thus this enzyme regulates the level of biologically active vitaminD and plays an important role in calcium homeostasis. Mutations inthis gene can result in vitamin D-dependent rickets type I.
Giroux, S., et al. Bone 47(5):975-981(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Holt, S.K., et al. Prostate 70(13):1448-1460(2010)Alzahrani, A.S., et al. J. Clin. Endocrinol. Metab. 95(9):4176-4183(2010)Sundqvist, E., et al. Eur. J. Hum. Genet. (2010) In press :
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