|Other Names||Proteinase-activated receptor 3, PAR-3, Coagulation factor II receptor-like 2, Thrombin receptor-like 2, F2RL2, PAR3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Highest expression in the megakaryocytes of the bone marrow, lower in mature megakaryocytes, in platelets and in a variety of other tissues such as heart and gut|
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Provided below are standard protocols that you may find useful for product applications.
Coagulation factor II (thrombin) receptor-like 2 (F2RL2)is a member of the large family of 7-transmembrane-region receptorsthat couple to guanosine-nucleotide-binding proteins. F2RL2 is alsoa member of the protease-activated receptor family and activated bythrombin. F2RL2 is activated by proteolytic cleavage of itsextracellular amino terminus. The new amino terminus functions as atethered ligand and activates the receptor. F2RL2 is a cofactor forF2RL3 activation by thrombin. It mediates thrombin-triggeredphosphoinositide hydrolysis and is expressed in a variety oftissues.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Popovic, M., et al. J. Thromb. Thrombolysis 30(2):164-171(2010)Van Laer, L., et al. Eur. J. Hum. Genet. 18(6):685-693(2010)Wysoczynski, M., et al. Mol. Cancer Res. 8(5):677-690(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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